|
Chỉ định và Liều dùng
Topical/Cutaneous
Psoriasis vulgaris Adult: As gel, oint, foam or susp containing betamethasone dipropionate 0.05% and calcipotriol 0.005%: Apply to affected area once daily. Duration of therapy: Up to 4 wk (scalp area) or 8 wk (non-scalp area). Treatment may be continued or repeated if necessary, after medical review and under regular medical supervision. Max: 15 g daily. Apply to max 30% of body surface.
|
|
Chống chỉ định
Known or suspected disorder of Ca metabolism. Erythrodermic, exfoliative and pustular psoriasis; viral lesions of the skin, fungal or bacterial skin infections, parasitic infections, skin manifestations in relation to TB, perioral dermatitis, atrophic skin, striae atrophicae, fragility of skin veins, ichthyosis, acne vulgaris, rosacea, ulcers and wounds.
|
|
Thận trọng
Patient w/ DM. Pregnancy and lactation.
|
|
Tác dụng không mong muốn
Allergic contact dermatitis, pruritus, headache, nasopharyngitis, psoriasis, rash, influenza, erythema, pain, burning sensation, eye irritation, dry skin, skin atrophy, folliculitis; reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycaemia and glucosuria. Rarely, hypercalcaemia or hypercalciuria, angioedema, facial oedema.
|
|
Topical: C
|
|
Thông tin tư vấn bệnh nhân
Avoid exposure to natural or artificial sunlight. Avoid application under occlusive dressings.
|
|
Chỉ số theo dõi
Monitor serum Ca level at baseline and periodically during treatment in patients at risk of hypercalcaemia.
|
|
Quá liều
Symptoms: Polyuria, constipation, muscle weakness, confusion, and coma; adrenal insufficiency. Management: Symptomatic treatment.
|
|
Tương tác
Additive adverse effects when used w/ other steroids.
|
|
Tác dụng
Description:
Mechanism of Action: Betamethasone is a synthetic corticosteroid that has anti-inflammatory, antipruritic and vasoconstrictive properties. Calcipotriol is a vit D analogue. It induces differentiation and suppresses proliferation of keratinocytes. However, the exact mechanism of their actions in psoriasis vulgaris are uncertain. Pharmacokinetics: Absorption: <1% is systemically absorbed through normal skin. Distribution: Enters breast milk (betamethasone). Plasma protein binding: Approx 64%. Metabolism: Rapidly and extensively metabolised in the liver. Excretion: Betamethasone: Via urine. Calcipotriol: Via faeces. |
|
Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Betamethasone, CID=9782, https://pubchem.ncbi.nlm.nih.gov/compound/Betamethasone (accessed on Jan. 21, 2020)  Source: National Center for Biotechnology Information. PubChem Database. Calcipotriol, CID=5288783, https://pubchem.ncbi.nlm.nih.gov/compound/Calcipotriol (accessed on Jan. 21, 2020) |
|
Bảo quản
Store between 20-25°C.
|
|
Phân loại MIMS
|
|
Phân loại ATC
D07XC01 - betamethasone ; Belongs to the class of potent (group III) corticosteroids in other combinations. Used in the treatment of dermatological diseases.
D05AX02 - calcipotriol ; Belongs to the class of other antipsoriatics for topical use. D07AC01 - betamethasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases. D05AX52 - calcipotriol, combinations ; Belongs to the class of other antipsoriatics for topical use. |
|
Tài liệu tham khảo
Anon. Calcipotriene and Betamethasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/09/2016. Calcipotriene 0.005% and Betamethasone dipropionate (Sandoz Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/09/2016. Joint Formulary Committee. Calcipotriol with Betamethasone. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/09/2016. McEvoy GK, Snow EK, Miller J et al (eds). Calcipotriene (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 08/09/2016. Taclonex Ointment (Warner Chilcott US, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/09/2016.
|
Đăng xuất
